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Pharmacogenomics · Drug Safety
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Medication Decisions

Upload your VCF file and instantly assess drug safety, dosage adjustments, and toxicity risks using CPIC-aligned pharmacogenomic analysis — tailored to your unique genetic profile.

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Analysis Tool

Pharmacogenomic Risk Analyzer

Upload your VCF file and select medications to receive personalized risk predictions with LLM-generated clinical explanations.

01

Upload VCF File

Variant Call Format v4.2

Drag & drop your VCF file here

or click to browse files

.vcf onlyMax 5 MB
02

Select Drug(s)

Click to toggle • supports multiple

VCF file required
Drugs required
Process

How PharmaGuard Works

From raw genomic data to clinically actionable insights in seconds.

01

Upload VCF File

Drag & drop or browse your Variant Call Format (.vcf) file. We validate structure, check for required INFO tags (GENE, STAR, RS), and parse pharmacogenomic variants.

Supports VCF v4.2 • Up to 5 MB
02

Select Drug(s)

Choose from supported drugs including Codeine, Warfarin, Clopidogrel, Simvastatin, Azathioprine, and Fluorouracil — or enter a custom drug name.

Single drug or comma-separated list
03

Get AI Analysis

Our AI analyzes your variants across 6 critical pharmacogenes, predicts risk levels, and generates LLM-powered clinical explanations with specific variant citations.

Color-coded risk • CPIC recommendations

Risk Classification

Safe— No dose adjustment needed
Adjust Dosage— Modified dosing recommended
Toxic— Risk of serious toxicity
Ineffective— Drug may not work
Unknown— Insufficient data
Features
Everything You Need,
All in One Place
Core Feature

Genomic Analysis

Upload your VCF file and get instant pharmacogenomic risk assessments across 6 genes — powered by CPIC guidelines.

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Family Planning

IVF & Genetic Compatibility

See how your genetics combine with your partner's to predict medication responses for your future children.

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Community

Genetic Twin Finder

Discover patients with matching genetic profiles. Share experiences and learn from people like you.

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Community

Community Feed

A dedicated forum for the pharmacogenomics community — post updates, ask questions, and upvote helpful answers.

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AI Powered

AI Report Assistant

Our Groq-powered chatbot explains your report in plain English — no jargon, just clear answers to your questions.

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Analysis

Drug Interaction Checker

Analyze how your body processes 20+ common drugs including Warfarin, Codeine, Clopidogrel, and Simvastatin.

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Drug–Gene Interactions

Key pharmacogenomic relationships analyzed by PharmaGuard

  • Prodrug → morphine conversion — Toxic if ultrarapid metabolizer

    CODEINECYP2D6

  • Warfarin clearance — Bleeding if poor metabolizer

    WARFARINCYP2C9

  • Prodrug activation — Ineffective if poor metabolizer

    CLOPIDOGRELCYP2C19

  • Hepatic uptake — Myopathy if *5 variant

    SIMVASTATINSLCO1B1

  • Thiopurine inactivation — Myelosuppression if poor metabolizer

    AZATHIOPRINETPMT

  • 5-FU catabolism — Severe toxicity if DPYD deficient

    FLUOROURACILDPYD

  • 5-FU catabolism — Severe toxicity if DPYD deficient

    FLUOROURACILDPYD

  • Thiopurine inactivation — Myelosuppression if poor metabolizer

    AZATHIOPRINETPMT

  • Hepatic uptake — Myopathy if *5 variant

    SIMVASTATINSLCO1B1

  • Prodrug activation — Ineffective if poor metabolizer

    CLOPIDOGRELCYP2C19

  • Warfarin clearance — Bleeding if poor metabolizer

    WARFARINCYP2C9

  • Prodrug → morphine conversion — Toxic if ultrarapid metabolizer

    CODEINECYP2D6

Genes & Drugs Covered

CYP2D6

Cytochrome P450 2D6

Metabolizes ~25% of all drugs

Key Drugs

CodeineTramadolTamoxifenAntidepressants

Common Variants

*1*2*4*5*10*17*41

CYP2C19

Cytochrome P450 2C19

Key in prodrug activation

Key Drugs

ClopidogrelPPIsAntidepressantsAntifungals

Common Variants

*1*2*3*17

CYP2C9

Cytochrome P450 2C9

Metabolizes narrow-TI drugs

Key Drugs

WarfarinNSAIDsPhenytoinSulfonylureas

Common Variants

*1*2*3*5*6

SLCO1B1

Solute Carrier Organic Anion 1B1

Hepatic drug uptake transporter

Key Drugs

SimvastatinAtorvastatinMethotrexate

Common Variants

*1a*1b*5*15*17

TPMT

Thiopurine S-Methyltransferase

Thiopurine drug inactivation

Key Drugs

Azathioprine6-MercaptopurineThioguanine

Common Variants

*1*2*3A*3B*3C

DPYD

Dihydropyrimidine Dehydrogenase

Fluoropyrimidine catabolism

Key Drugs

Fluorouracil (5-FU)CapecitabineTegafur

Common Variants

*1*2AHapB3c.2846A>T

Start Your Pharmacogenomic Journey

Upload your VCF file and get your first analysis in under 30 seconds.

Get Started
PharmaGuard

AI-powered pharmacogenomic risk analysis. Helping clinicians and researchers make safer, personalised medication decisions.

Research Use Only

Resources

  • CPIC Guidelines
  • PharmGKB
  • VCF Format Spec
  • dbSNP

Genes

  • CYP2D6
  • CYP2C19
  • CYP2C9
  • SLCO1B1
  • TPMT
  • DPYD

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  • How It Works
  • Analyze VCF
  • Genes & Drugs
  • Community